Molecular evolution: dynamic combinatorial libraries, autocatalytic networks and the quest for molecular function

被引：140

作者：

Cousins, GRL ^{[1
]}

Poulsen, SA ^{[1
]}

Sanders, JKM ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 03期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1016/S1367-5931(00)00088-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The principles of Darwinian evolution have been explored in molecular systems such as autocatalytic networks and dynamic combinatorial libraries. Molecular evolution in such systems manifests itself as ligand or receptor amplification by selection. Research efforts exploring these concepts may provide a mechanism far the identification of novel catalysts, molecular receptors and bioactive molecules.

引用

页码：270 / 279

页数：10

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