Antioxidant activity of β-blockers:: An effect mediated by scavenging reactive oxygen and nitrogen species?

被引：78

作者：

Gomes, Ana ^{[1
]}

Costa, David ^{[1
]}

Lima, Jose L. F. C. ^{[1
]}

Fernandes, Eduarda ^{[1
]}

机构：

[1] Univ Porto, Dept Quim Fis, REQUIMTE, Fac Farm, P-4099030 Oporto, Portugal

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 13期

关键词：

beta-blockers; cardiovascular disease; antioxidant activity; reactive oxygen species; reactive nitrogen species; scavenging activity;

D O I：

10.1016/j.bmc.2006.02.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The therapeutic effects of beta-blockers are normally explained by their capacity to block the beta-adrenoceptors, however, some of the beneficial cardiovascular effects shown by this group of compounds have already been associated with the antioxidant properties that some of them seem to possess. The beta-blockers atenolol, labetalol, metoprolol, pindolol, propranolol, sotalol, timolol, and carvedilol were tested for their putative scavenging activity for ROS (O-2(center dot-), H2O2, HO center dot, HOCl, and ROO center dot) and RNS ((NO)-N-center dot and ONOO-). Some of the studied compounds are effective ROS and/or RNS scavengers, these effects being possibly useful in preventing oxidative damage verified in hypertension as well as in other cardiovascular diseases that frequently emerge in association with oxidative stress. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4568 / 4577

页数：10

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