Unique microRNA molecular profiles in lung cancer diagnosis and prognosis

被引：2848

作者：

Yanaihara, N

Caplen, N

Bowman, E

Seike, M

Kumamoto, K

Yi, M

Stephens, RM

Okamoto, A

Yokota, J

Tanaka, T

Colin, GA

Liu, CG

Croce, CM

Harris, CC ^{[1
]}

机构：

[1] NCI, Human Carcinogenesis Lab, Canc Res Ctr, NIH, Bethesda, MD 20892 USA

[2] NCI, Gene Silencing Sect, Off Sci & Technol Partnership, Ctr Canc Res,NIH, Bethesda, MD 20892 USA

[3] SAIC Frederick Inc, NCI Frederick, Adv Biomed Comp Ctr, Ft Detrick, MD 21702 USA

[4] Jikei Univ, Sch Med, Dept Obstet & Gynecol, Tokyo 1058461, Japan

[5] Natl Canc Ctr, Inst Res, Div Biol, Tokyo 1040045, Japan

[6] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

CANCER CELL | 2006年 / 9卷 / 03期

关键词：

D O I：

10.1016/j.ccr.2006.01.025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNA (miRNA) expression profiles for lung cancers were examined to investigate miRNA's involvement in lung carcinogenesis. miRNA microarray analysis identified statistical unique profiles, which could discriminate lung cancers from noncancerous lung tissues as well as molecular signatures that differ in tumor histology. miRNA expression profiles correlated with survival of lung adenocarcinomas, including those classified as disease stage 1. High hsa-mir-155 and low hsa-let-7a-2 expression correlated with poor survival by univariate analysis as well as multivariate analysis for hsa-mir-155. The miRNA expression signature on outcome was confirmed by real-time RT-PCR analysis of precursor miRNAs and crossvalidated with an independent set of adenocarcinomas. These results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer.

引用

收藏

页码：189 / 198

页数：10

相关论文

共 48 条

[1] MicroRNA pathways in flies and worms: Growth, death, fat, stress, and timing [J].

Ambros, V .

CELL, 2003, 113 (06) :673-676

[2] Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes [J].

Baskerville, S ;

Bartel, DP .

RNA, 2005, 11 (03) :241-247

[3] Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16Ink4a-p19Arf pathway [J].

Bulavin, DV ;

Phillips, C ;

Nannenga, B ;

Timofeev, O ;

Donehower, LA ;

Anderson, CW ;

Appella, E ;

Fornace, AJ .

NATURE GENETICS, 2004, 36 (04) :343-350

[4] Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity [J].

Bulavin, DV ;

Demidov, ON ;

Saito, S ;

Kauraniemi, P ;

Phillips, C ;

Amundson, SA ;

Ambrosino, C ;

Sauter, G ;

Nebreda, AR ;

Anderson, CW ;

Kallioniemi, A ;

Fornace, AJ ;

Appella, E .

NATURE GENETICS, 2002, 31 (02) :210-215

[5] Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia [J].

Calin, GA ;

Dumitru, CD ;

Shimizu, M ;

Bichi, R ;

Zupo, S ;

Noch, E ;

Aldler, H ;

Rattan, S ;

Keating, M ;

Rai, K ;

Rassenti, L ;

Kipps, T ;

Negrini, M ;

Bullrich, F ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) :15524-15529

[6] Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers [J].

Calin, GA ;

Sevignani, C ;

Dan Dumitru, C ;

Hyslop, T ;

Noch, E ;

Yendamuri, S ;

Shimizu, M ;

Rattan, S ;

Bullrich, F ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) :2999-3004

[7] A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia [J].

Calin, GA ;

Ferracin, M ;

Cimmino, A ;

Di Leva, G ;

Shimizu, M ;

Wojcik, SE ;

Iorio, MV ;

Visone, R ;

Sever, NI ;

Fabbri, M ;

Iuliano, R ;

Palumbo, T ;

Pichiorri, F ;

Roldo, C ;

Garzon, R ;

Sevignani, C ;

Rassenti, L ;

Alder, H ;

Volinia, S ;

Liu, CG ;

Kipps, TJ ;

Negrini, M ;

Croce, CM .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (17) :1793-1801

[8] MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias [J].

Calin, GA ;

Liu, CG ;

Sevignani, C ;

Ferracin, M ;

Felli, N ;

Dumitru, CD ;

Shimizu, M ;

Cimmino, A ;

Zupo, S ;

Dono, M ;

Dell'Aquila, ML ;

Alder, H ;

Rassenti, L ;

Kipps, TJ ;

Bullrich, F ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (32) :11755-11760

[9] MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells [J].

Chan, JA ;

Krichevsky, AM ;

Kosik, KS .

CANCER RESEARCH, 2005, 65 (14) :6029-6033

[10] Histone acetylation: a switch between repressive and permissive chromatin - Second in review series on chromatin dynamics [J].

Eberharter, A ;

Becker, PB .

EMBO REPORTS, 2002, 3 (03) :224-229

← 1 2 3 4 5 →