Molecular mechanisms of taste transduction in vertebrates

被引：42

作者：

Ishimaru, Yoshiro ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Bunkyo Ku, Tokyo 1138657, Japan

来源：

ODONTOLOGY | 2009年 / 97卷 / 01期

关键词：

Taste receptor; Basic taste quality; Signal transduction; Taste coding; Gene knockout mice; BITTER RECEPTOR GENES; SWEET TASTE; SOUR-TASTE; MAMMALIAN TASTE; CATION CHANNEL; SALT TASTE; TRANSMEMBRANE DOMAIN; TRANSIENT RECEPTOR; POSITIONAL CLONING; UMAMI TASTE;

D O I：

10.1007/s10266-008-0095-y

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Among the five senses, taste and olfaction play crucial roles in the detection of chemical substances in the environment and are referred to as chemical senses. In the past decade, much progress has been made in studies on molecular mechanisms of the gustatory system by methods such as those based on molecular and cellular biology, genetics, and bioinformatics. This review covers recent studies on taste receptors, intracellular signaling transduction in taste receptor cells, and taste coding at the periphery in vertebrates from fish to mammals.

引用

页码：1 / 7

页数：7

共 88 条

[1] Studies on taste: Molecular biology and food science [J].

Abe, Keiko .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2008, 72 (07) :1647-1656

[2] A novel family of mammalian taste receptors [J].

Adler, E ;

Hoon, MA ;

Mueller, KL ;

Chandrashekar, J ;

Ryba, NJP ;

Zuker, CS .

CELL, 2000, 100 (06) :693-702

[3] Co-expression of calcium signaling components in vertebrate taste bud cells [J].

Asano-Miyoshi, M ;

Abe, K ;

Emori, Y .

NEUROSCIENCE LETTERS, 2000, 283 (01) :61-64

[4] IP3 receptor type 3 and PLCβ2 are co-expressed with taste receptors T1R and T2R in rat taste bud cells [J].

Asano-Miyoshi, M ;

Abe, K ;

Emori, Y .

CHEMICAL SENSES, 2001, 26 (03) :259-265

[5] AMILORIDE-BLOCKABLE SODIUM CURRENTS IN ISOLATED TASTE RECEPTOR-CELLS [J].

AVENET, P ;

LINDEMANN, B .

JOURNAL OF MEMBRANE BIOLOGY, 1988, 105 (03) :245-255

[6] Positional cloning of the mouse saccharin preference (Sac) locus [J].

Bachmanov, AA ;

Li, X ;

Reed, DR ;

Ohmen, JD ;

Li, SR ;

Chen, ZY ;

Tordoff, MG ;

de Jong, PJ ;

Wu, CY ;

West, DB ;

Chatterjee, A ;

Ross, DA ;

Beauchamp, GK .

CHEMICAL SENSES, 2001, 26 (07) :925-933

[7] Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type I cells in taste buds [J].

Bartel, Dianna L. ;

Sullivan, Susan L. ;

Lavoie, Elise G. ;

Sevigny, Jean ;

Finger, Thomas E. .

JOURNAL OF COMPARATIVE NEUROLOGY, 2006, 497 (01) :1-12

[8] The human taste receptor hTAS2R14 responds to a variety of different bitter compounds [J].

Behrens, M ;

Brockhoff, A ;

Kuhn, C ;

Bufe, B ;

Winnig, M ;

Meyerhof, W .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 319 (02) :479-485

[9] Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium [J].

Brockhoff, Anne ;

Behrens, Maik ;

Massarotti, Alberto ;

Appendino, Giovanni ;

Meyerhof, Wolfgang .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 55 (15) :6236-6243

[10] The human TAS2R16 receptor mediates bitter taste in response to β-glucopyranosides [J].

Bufe, B ;

Hofmann, T ;

Krautwurst, D ;

Raguse, JD ;

Meyerhof, W .

NATURE GENETICS, 2002, 32 (03) :397-401

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