Neutrophil extracellular traps: Is immunity the second function of chromatin?

被引：766

作者：

Brinkmann, Volker ^{[1
]}

Zychlinsky, Arturo ^{[2
]}

机构：

[1] Max Planck Inst Infect Biol, Microscopy Core Facil, D-10117 Berlin, Germany

[2] Max Planck Inst Infect Biol, Dept Cellular Microbiol, D-10117 Berlin, Germany

来源：

JOURNAL OF CELL BIOLOGY | 2012年 / 198卷 / 05期

关键词：

GROUP-A STREPTOCOCCUS; ANTIMICROBIAL ACTIVITY; INNATE IMMUNITY; NETTING NEUTROPHILS; MITOCHONDRIAL-DNA; NET FORMATION; HISTONES; RELEASE; INDUCE; PEPTIDE;

D O I：

10.1083/jcb.201203170

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Neutrophil extracellular traps (NETs) are made of processed chromatin bound to granular and selected cytoplasmic proteins. NETs are released by white blood cells called neutrophils, maybe as a last resort, to control microbial infections. This release of chromatin is the result of a unique form of cell death, dubbed "NETosis." Here we review our understanding of how NETs are made, their function in infections and as danger signals, and their emerging importance in autoimmunity and coagulation.

引用

页码：773 / 783

页数：11

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