Apoptosis: a potential target for discovering novel therapies for cardiovascular diseases

被引：35

作者：

Yue, TL ^{[1
]}

Ohlstein, EH

Ruffolo, RR

机构：

[1] SmithKline Beecham Pharmaceut, Dept Cardiovasc Pharmacol, King Of Prussia, PA 19406 USA

[2] SmithKline Beecham Pharmaceut, Biol Sci, King Of Prussia, PA 19406 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1999年 / 3卷 / 04期

关键词：

D O I：

10.1016/S1367-5931(99)80069-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The realization that apoptosis is genetically programmed raises the exciting prospect that modulating apoptosis may provide novel approaches for treatment of cardiovascular diseases in which apoptosis has been demonstrated. Low molecular weight inhibitors of caspases and mitogen-activated protein kinases have been evaluated, with promising results in a variety of cardiovascular apoptotic models.

引用

页码：474 / 480

页数：7

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