Talk is cheap-cross-talk in establishment, maintenance, and readout of chromatin modifications

被引：39

作者：

Fischle, Wolfgang ^{[1
]}

机构：

[1] Max Planck Inst Biophys Chem, Lab Chromatin Biochem, D-37077 Gottingen, Germany

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 24期

关键词：

Neurospora crassa; DNA methylation; protein phosphatase PP1; Histone H3 Ser 10 phosphorylation; histone H3 mutation;

D O I：

10.1101/gad.1759708

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The functionality of a cell's genome is controlled epigenetically on the level of chromatin. Multiple post-translational modifications of histone proteins together with DNA methylation play a key role in directing distinct functional states of chromatin. As it emerges, many epigenetic marks on the chromatin platform do not act independently, but cross-talk with each other. In this issue of Genes & Development, Adhvaryu and Selker (pp. 3391-3396) provide novel insights into an intricate regulatory network involving histone phosphorylation, histone methylation, and DNA methylation.

引用

页码：3375 / 3382

页数：8

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