Loss-of-function alleles of the JIL-1 histone H3S10 kinase enhance position-effect variegation at pericentric sites in Drosophila heterochromatin

被引：34

作者：

Bao, Xiaomin ^{[1
]}

Deng, Huai ^{[1
]}

Johansen, Jorgen ^{[1
]}

Girton, Jack ^{[1
]}

Johansen, Kristen M. ^{[1
]}

机构：

[1] Iowa State Univ, Dept Biochem Biophys & Mol Biol, Ames, IA 50011 USA

来源：

GENETICS | 2007年 / 176卷 / 02期

关键词：

D O I：

10.1534/genetics.107.073676

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In this study we show that loss-of-function alleles of the JIL-1 histone H3S10 kinase act as enhancers of position-effect variegation at pericentric sites whereas the gain-of-function JIL-1(Su(var)3-1[3]) allele acts as a suppressor strongly supporting a functional role for JIL-1 in maintaining euchromatic chromatin and counteracting heterochromatic spreading and gene silencing.

引用

页码：1355 / 1358

页数：4

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