Long-Term Dynamics of Adaptation in Asexual Populations

被引：350

作者：

Wiser, Michael J. ^{[1
,2
]}

Ribeck, Noah ^{[1
,3
]}

Lenski, Richard E. ^{[1
,2
,3
]}

机构：

[1] Michigan State Univ, BEACON Ctr Study Evolut Act, E Lansing, MI 48824 USA

[2] Michigan State Univ, Dept Zool, E Lansing, MI 48824 USA

[3] Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA

来源：

SCIENCE | 2013年 / 342卷 / 6164期

基金：

美国国家科学基金会;

关键词：

ESCHERICHIA-COLI; EXPERIMENTAL EVOLUTION; BENEFICIAL MUTATIONS; BACTERIAL POPULATION; CLONAL INTERFERENCE; FITNESS LANDSCAPES; EPISTASIS; SELECTION;

D O I：

10.1126/science.1243357

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Experimental studies of evolution have increased greatly in number in recent years, stimulated by the growing power of genomic tools. However, organismal fitness remains the ultimate metric for interpreting these experiments, and the dynamics of fitness remain poorly understood over long time scales. Here, we examine fitness trajectories for 12 Escherichia coli populations during 50,000 generations. Mean fitness appears to increase without bound, consistent with a power law. We also derive this power-law relation theoretically by incorporating clonal interference and diminishing-returns epistasis into a dynamical model of changes in mean fitness over time.

引用

页码：1364 / 1367

页数：4

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