Synthesis and preliminary pharmacological evaluation of thiophene analogues of viloxazine as potential antidepressant drugs

被引：29

作者：

Corral, C

Lissavetzky, J

Manzanares, I

Darias, V

Expósito-Orta, MA

Conde, JAM

Sánchez-Mateo, CC

机构：

[1] CSIC, Inst Quim Med, E-28006 Madrid, Spain

[2] Univ La Laguna, Fac Farm, Dept Farmacognosia & Farmacodinamia, Tenerife, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1999年 / 7卷 / 07期

关键词：

thiophene; viloxazine; antidepressant; synthesis; pharmacology;

D O I：

10.1016/S0968-0896(99)00070-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of eight thienyloxymethylmorpholines, thiophene analogues of viloxazine, have been synthesized by three different routes. The preliminary pharmacological evaluation of this series shows antidepressant properties on the mice models used with a light sedative action. The structure-activity relationship is established in a first approximation. (C) 1999 Elsevier Science Ltd. All rights reserved.

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收藏

页码：1349 / 1359

页数：11

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