Glucagon-like peptide 1 and appetite

被引：138

作者：

Dailey, Megan J. ^{[1
]}

Moran, Timothy H. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2013年 / 24卷 / 02期

关键词：

GLP-1; appetite; gastrointestinal motility; food intake; DEPENDENT INSULINOTROPIC POLYPEPTIDE; REDUCE FOOD-INTAKE; CAUDAL BRAIN-STEM; GLP-1; 7-36; AMIDE; GENE-EXPRESSION; DIPEPTIDYL PEPTIDASE-4; RECEPTOR STIMULATION; DIFFERENT MECHANISMS; GLUCOSE-HOMEOSTASIS; NUCLEUS-ACCUMBENS;

D O I：

10.1016/j.tem.2012.11.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucagon-like peptide 1 (GLP-1) and GLP-1 analogs have received much recent attention due to the success of GLP-1 mimetics in treating type II diabetes mellitus (T2DM), but these compounds may also have the potential to treat obesity. The satiety effect of GLP-1 may involve both within-meal enteroenteric reflexes, and across-meal central signaling mechanisms, that mediate changes in appetite and promote satiety. Here, we review data supporting the role of both peripheral and central GLP-1 signaling in the control of gastrointestinal motility and food intake. Understanding the mechanisms underlying the appetite-suppressive effects of GLP-1 may help in developing targeted treatments for obesity.

引用

页码：85 / 91

页数：7

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