Safety, tolerability and immunogenicity of low dose Haemophilus influenzae type b conjugated to the outer membrane protein complex of Neisseria meningitidis group B

被引：7

作者：

Anderson, EL ^{[1
]}

Frey, S ^{[1
]}

Geldmacher, K ^{[1
]}

Radley, D ^{[1
]}

Lee, A ^{[1
]}

Donnelly, J ^{[1
]}

Mendelman, PM ^{[1
]}

Dargan, JM ^{[1
]}

Kaplan, KM ^{[1
]}

机构：

[1] Merck & Co Inc, West Point, PA 19486 USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2002年 / 21卷 / 04期

关键词：

Haemophilus influenzae type b disease; Haemophilus influenzae type b conjugate vaccine; conjugate vaccines; anti-PRP; PRP-OMPC;

D O I：

10.1097/00006454-200204000-00019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infants vaccinated with three doses followed by a booster of either 1.0 mug of Haemophilus influenzae type b conjugated to the outer membrane protein complex of Neisseria meningitidis group B or H. influenzae 10-mug oligosaccharide vaccine conjugated to 25 mug mutant toxin (CRM197) isolated from Corynebacterium diphtheriae had protective anti-polyribosylribitol phosphate concentrations.

引用

页码：350 / 352

页数：3

共 17 条

[11] Economisation of vaccination against Haemophilus influenzae type b:: a randomised trial of immunoaffinity of fractional-dose and two-dose regimens [J].