Crystal structure of ciprofloxacin hexahydrate and its characterization

被引：120

作者：

Turel, I ^{[1
]}

Bukovec, P ^{[1
]}

Quiros, M ^{[1
]}

机构：

[1] UNIV GRANADA,DEPT QUIM INORGAN,GRANADA 18071,SPAIN

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1997年 / 152卷 / 01期

关键词：

quinolone; ciprofloxacin; synthesis of a hydrate; crystal structure; zwitterion; characterization;

D O I：

10.1016/S0378-5173(97)04913-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ciprofloxacin hexahydrate has been prepared and its crystal structure has been determined by X-ray crystallography. The molecule is in the zwitterionic form in solid state, the carboxylic proton being present at terminal piperazine nitrogen atom (N(74)) which is in contrast to the previously reported structures of quinolones. Water molecules are involved in a very complicated hydrogen bonding network. Different other techniques (IR, Raman spectroscopy, thermal and elemental analysis) were used to characterize the title compound and to compare its properties with similar compounds. (C) 1997 Elsevier Science B.V.

引用

收藏

页码：59 / 65

页数：7

相关论文

共 16 条

[1] NALIDIXIC-ACID [J].

ACHARI, A ;

NEIDLE, S .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1976, 32 (FEB15) :600-602

[2] THE STRUCTURE OF SILVER PEFLOXACIN, AN ANTIBIOTIC RELATED TO NALIDIXIC-ACID [J].

BAENZIGER, NC ;

FOX, CL ;

MODAK, SL .

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1986, 42 :1505-1509

[3] RELATIONSHIPS BETWEEN THE CARBON-OXYGEN STRETCHING FREQUENCIES OF CARBOXYLATO COMPLEXES AND THE TYPE OF CARBOXYLATE COORDINATION [J].

DEACON, GB ;

PHILLIPS, RJ .

COORDINATION CHEMISTRY REVIEWS, 1980, 33 (03) :227-250

[4]

GOLIC L, 1992, JOINT SLOV CROAT CRY, P25

[5] DISSOCIATION AND COMPLEXATION OF FLUOROQUINOLONE ANALOGS [J].

LEE, DS ;

HAN, HJ ;

KIM, K ;

PARK, WB ;

CHO, JK ;

KIM, JH .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1994, 12 (02) :157-164

[6]

Mazuel C, 1991, ANAL PROFILES DRUG S, P557

[7]

Reynolds J. E. F., 1993, MARTINDALE EXTRA PHA, P145

[8] CHARACTERIZATION OF THE COMPLEXATION OF FLUOROQUINOLONE ANTIMICROBIALS WITH METAL-IONS BY NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY [J].

RILEY, CM ;

ROSS, DL ;

VANDERVELDE, D ;

TAKUSAGAWA, F .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1993, 11 (01) :49-59

[9] STRUCTURE OF THE ANTIMICROBIAL AGENT CINOXACIN [J].

ROSALES, MJ ;

TOSCANO, RA ;

BARBABEHRENS, N ;

GARCIA, J .

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1985, 41 :1825-1826

[10] A PHYSICOCHEMICAL STUDY OF THE INTERACTION OF CIPROFLOXACIN AND OFLOXACIN WITH POLYVALENT CATIONS [J].

SANCHEZ, BM ;

CABARGA, MM ;

NAVARRO, AS ;

HURLE, ADG .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1994, 106 (03) :229-235