Retrotransposons revisited: The restraint and rehabilitation of parasites

被引：456

作者：

Goodier, John L. ^{[1
]}

Kazazian, Haig H., Jr. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA

来源：

CELL | 2008年 / 135卷 / 01期

关键词：

D O I：

10.1016/j.cell.2008.09.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Retrotransposons, mainly LINEs, SINEs, and endogenous retroviruses, make up roughly 40% of the mammalian genome and have played an important role in genome evolution. Their prevalence in genomes reflects a delicate balance between their further expansion and the restraint imposed by the host. In any human genome only a small number of LINE1s (L1s) are active, moving their own and SINE sequences into new genomic locations and occasionally causing disease. Recent insights and new technologies promise answers to fundamental questions about the biology of transposable elements.

引用

页码：23 / 35

页数：13

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