Immunosenescence phenotypes in the telomerase knockout mouse

被引：36

作者：

Blasco, MA ^{[1
]}

机构：

[1] CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain

来源：

SPRINGER SEMINARS IN IMMUNOPATHOLOGY | 2002年 / 24卷 / 01期

关键词：

D O I：

10.1007/s00281-001-0096-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Increasing generations of the telomerase knockout mouse, Terc(-/-), show severe telomere dysfunction characterized by critically short telomeres and end-to-end chromosomal fusions. These mice also suffer from various age-related diseases affecting highly proliferative tissues. Among these pathologies are a reduced proliferative capacity of B and T cells, as well as a reduction of germinal center reactivity upon immunization. Both immune system defects are landmarks of immunosenescence. The study of the telomerase-deficient mouse model supports the notion that telomere shortening with age contributes to immunological dysfunction in the elderly.

引用

页码：75 / 85

页数：11

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