(+)-trienomycins A, B, C, and F and (+)-mycotrienins I and II: Relative and absolute stereochemistry

被引：35

作者：

Smith, AB

Wood, JL

Wong, W

Gould, AE

Rizzo, CJ

Barbosa, J

Komiyama, K

Omura, S

机构：

[1] UNIV PENN,RES STRUCT MATTER LAB,PHILADELPHIA,PA 19104

[2] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN

[3] KITASATO INST,MINATO KU,TOKYO 108,JAPAN

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1996年 / 118卷 / 35期

关键词：

D O I：

10.1021/ja961400i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The complete relative and absolute stereochemistries have been elucidated for the ansamycin antibiotics (+)-trienomycins A, B, and C and their potent antifungal congeners, the (+)-mycotrienins I and II. A new species, (+)-trienomycin F, has also been isolated and characterized. In addition, an end-game synthetic strategy for the trienomycins and mycotrienins has been developed.

引用

页码：8308 / 8315

页数：8