Quantitative Assessment of Nipple Perfusion With Near-Infrared Fluorescence Imaging

被引：12

作者：

Ashitate, Yoshitomo ^{[1
,2
]}

Lee, Bernard T. ^{[3
]}

Ngo, Long H. ^{[4
]}

Laurence, Rita G. ^{[1
]}

Hutteman, Merlijn ^{[1
,5
]}

Oketokoun, Rafiou ^{[1
]}

Lunsford, Elaine ^{[1
]}

Choi, Hak Soo ^{[1
]}

Frangioni, John V. ^{[1
,6
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA

[2] Hokkaido Univ, Grad Sch Med, Div Canc Diagnost & Therapeut, Sapporo, Hokkaido, Japan

[3] Beth Israel Deaconess Med Ctr, Dept Surg, Div Plast & Reconstruct Surg, Boston, MA 02215 USA

[4] Beth Israel Deaconess Med Ctr, Dept Med, Div Gen Med & Primary Care, Boston, MA 02215 USA

[5] Leiden Univ, Med Ctr, Dept Surg, Leiden, Netherlands

[6] Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA

来源：

ANNALS OF PLASTIC SURGERY | 2013年 / 70卷 / 02期

基金：

美国国家卫生研究院;

关键词：

nipple-sparing mastectomy; nipple-areolar complex; periareolar incision; radial incision; indocyanine green; methylene blue; near-infrared fluorescence imaging; SKIN-SPARING MASTECTOMY; IMMEDIATE BREAST RECONSTRUCTION; PERFORATOR FLAP DESIGN; PATIENT-SATISFACTION; AREOLA COMPLEX; CANCER; RISK; IDENTIFICATION; COMPLICATIONS; ANGIOGRAPHY;

D O I：

10.1097/SAP.0b013e31822f9af7

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Preserving the nipple-areolar complex with a nipple-sparing mastectomy improves cosmesis compared with skin-sparing mastectomy. However, complications such as necrosis of the nipple-areolar complex significantly affect cosmetic outcome. Many factors influence nipple-areolar perfusion, and no consensus currently exists on optimal incisional choice. This study evaluates 2 nipple-sparing mastectomy incision models using near-infrared fluorescence to assess perfusion quantitatively. The periareolar and radial incisions were compared with 2 control models in Yorkshire pigs (N = 6). Methylene blue and indocyanine green were injected intravenously, and near-infrared fluorescence images were recorded at 3 time points: before surgery, immediately after (0 hour), and 3 days postoperatively. Contrast-to-background ratio was used to assess perfusion. At 72 hours, radial incisions showed a statistically significantly higher perfusion compared with periareolar incisions (P < 0.05). Based on our findings, radial incisions for nipple-sparing mastectomy may be preferable due to higher perfusion; however, clinical trials are necessary for further assessment.

引用

页码：149 / 153

页数：5

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