Novel glucocorticoid antedrugs possessing a 21-(γ-lactone) ring

被引：11

作者：

Angell, RM ^{[1
]}

Biggadike, K ^{[1
]}

Farrell, RM ^{[1
]}

Flack, SS ^{[1
]}

Hancock, AP ^{[1
]}

Irving, WR ^{[1
]}

Lynn, SM ^{[1
]}

Procopiou, PA ^{[1
]}

机构：

[1] GlaxoSmithKline Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2002年 / 06期

关键词：

D O I：

10.1039/b200190j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel pregnane derivatives bearing gamma-butyrolactones at C21 were prepared and tested as glucocorticoid agonists. The compounds were also tested for their lability in human plasma, and found to be rapidly hydrolysed by the enzyme paraoxonase to the respective hydroxyacids.

引用

页码：831 / 839

页数：9

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