Effects of heme oxygenase-1 inducers on established rat adjuvant arthritis

被引：9

作者：

Devesa, I ^{[1
]}

Ferrándiz, ML ^{[1
]}

Busserolles, J ^{[1
]}

Alcaraz, MJ ^{[1
]}

机构：

[1] Univ Valencia, Dept Pharmacol, E-46100 Valencia, Spain

来源：

CELLULAR AND MOLECULAR BIOLOGY | 2005年 / 51卷 / 05期

关键词：

heme oxygenase-1; adjuvant arthritis; chronic inflammation; nitric oxide; tumor necrosis factor-alpha;

D O I：

10.1170/T653

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heme oxygenase-1 (HO-1) activity can inhibit inflammatory and immune responses. We have examined the influence of HO-1 induction on the established rat adjuvant arthritis model of chronic inflammation. Therapeutic administration of cobalt protoporphyrin IX (CoPP; 5 mg/kg/day i.p.) from day 17 to 23 significantly reduced the inflammatory response, with partial inhibition of hind paw edema and the production of some inflammatory mediators such as nitric oxide metabolites and tumor necrosis factor-alpha, although joint erosion was observed. Hemin administration (26 mg/kg/day i.p.) during the same time period was ineffective on these parameters. Western blot analysis of hind paw homogenates revealed a weaker induction of HO-1 by this compound in comparison with CoPP. Our data indicate that pharmacological HO-1 induction after the establisment of adjuvant arthritis partially reduced the inflammatory response but it was not sufficient to control joint erosion in our experimental conditions.

引用

页码：479 / 485

页数：7

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