Particulate matter, oxidative stress and neurotoxicity

被引：156

作者：

MohanKumar, Sheba M. J. ^{[2
]}

Campbell, Arezoo ^{[3
]}

Block, Michelle ^{[4
]}

Veronesi, Bellina ^{[1
]}

机构：

[1] US Environm Protect Agcy, Natl Hlth & Environm Effects Res Lab, Div Neurotoxicol, Res Triangle Pk, NC USA

[2] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA

[3] Western Univ Hlth Sci, Dept Pharmaceut Sci, Pomona, CA USA

[4] Virginia Commonwealth Univ Med Campus, Dept Anat & Neurobiol, Richmond, VA USA

来源：

NEUROTOXICOLOGY | 2008年 / 29卷 / 03期

关键词：

particulate matter; oxidative stress; innate immunity; neurotoxicity; Mac-1; HPA axis;

D O I：

10.1016/j.neuro.2007.12.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Particulate matter (PM), a component of air pollution has been epidemiologically associated with sudden deaths, cardiovascular and respiratory illnesses. The effects are more pronounced in patients with pre-existing conditions such as asthma, diabetes or obstructive pulmonary disorders. Clinical and experimental studies have historically focused on the cardiopulmonary effects of PM. However, since PM particles carry numerous biocontaminants that are capable of triggering free radical production and cytokine release, the possibility that PM may affect organs systems sensitive to oxidative stress must be considered. Four independent studies that summarize the neurochemical and neuropathological changes found in the brains of PM exposed animals are described here. These were recently presented at two 2007 symposia sponsored by the Society of Toxicology (Charlotte, NC) and the International Neurotoxicology Association (Monterey, CA). (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：479 / 488

页数：10

共 81 条

[21] Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation [J].

Gurgueira, SA ;

Lawrence, J ;

Coull, B ;

Murthy, GGK ;

González-Flecha, B .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2002, 110 (08) :749-755

[22] Mental stress-induced myocardial ischemia in coronary artery disease patients with left ventricular dyshinction [J].

Hassan, Mustafa ;

York, Kaki M. ;

Li, Haihong ;

Li, Qin ;

Sheps, David S. .

JOURNAL OF NUCLEAR CARDIOLOGY, 2007, 14 (03) :308-313

[23] Cytokine release from alveolar macrophages exposed to ambient particulate matter: Heterogeneity in relation to size, city and season [J].

Hetland, Ragna B. ;

Cassee, Flemming R. ;

Lag, Marit ;

Refsnes, Magne ;

Dybing, Erik ;

Schwarze, Per E. .

PARTICLE AND FIBRE TOXICOLOGY, 2005, 2 (01)

[24]

HSU A, 2007, INT J NEUROPROTECTIO, V3, P107

[25]

Huang CS, 2001, CANCER RES, V61, P8051

[26] Apoptotic and inflammatory effects induced by different particles in human alveolar macrophages [J].

Huang, YCT ;

Li, ZW ;

Harder, SD ;

Soukup, JM .

INHALATION TOXICOLOGY, 2004, 16 (14) :863-878

[27] Effects of organic chemicals derived from ambient particulate matter on lung inflammation related to lipopolysaccharide [J].

Inoue, Ken-ichiro ;

Takano, Hirohisa ;

Yanagisawa, Rie ;

Hirano, Seishiro ;

Kobayashi, Takahiro ;

Ichinose, Takamichi ;

Yoshikawa, Toshikazu .

ARCHIVES OF TOXICOLOGY, 2006, 80 (12) :833-838

[28]

Ising H, 2004, Noise Health, V6, P21

[29]

Kajko-Mattsson M, 2001, FIFTH EUROPEAN CONFERENCE ON SOFTWARE MAINTENANCE AND REENGINEERING, PROCEEDINGS, P1, DOI 10.1109/CSMR.2001.914962

[30] Versatile aerosol concentration enrichment system (VACES) for simultaneous in vivo and in vitro evaluation of toxic effects of ultrafine, fine and coarse ambient particles - Part II: Field evaluation [J].

Kim, S ;

Jaques, PA ;

Chang, MC ;

Barone, T ;

Xiong, C ;

Friedlander, SK ;

Sioutas, C .

JOURNAL OF AEROSOL SCIENCE, 2001, 32 (11) :1299-1314

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