Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset

被引：910

作者：

Veldhoen, Marc ^{[1
]}

Uyttenhove, Catherine ^{[2
,3
]}

van Snick, Jacques ^{[2
,3
]}

Helmby, Helena ^{[4
]}

Westendorf, Astrid ^{[5
]}

Buer, Jan ^{[5
]}

Martin, Bruno ^{[1
]}

Wilhelm, Christoph ^{[1
]}

Stockinger, Brigitta ^{[1
]}

机构：

[1] Natl Inst Med Res, MRC, Div Mol Immunol, London NW7 1AA, England

[2] Catholic Univ Louvain, Ludwig Inst Canc Res, Brussels Branch, Cellular Genet Unit, B-1200 Brussels, Belgium

[3] Catholic Univ Louvain, Christian de Duve Inst Cellular Pathol, Expt Med Unit, B-1200 Brussels, Belgium

[4] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England

[5] Univ Duisburg Essen, Inst Med Microbiol, D-45122 Essen, Germany

来源：

NATURE IMMUNOLOGY | 2008年 / 9卷 / 12期

关键词：

D O I：

10.1038/ni.1659

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Since the discovery of T helper type 1 and type 2 effector T cell subsets 20 years ago, inducible regulatory T cells and interleukin 17 (IL-17)-producing T helper cells have been added to the 'portfolio' of helper T cells. It is unclear how many more effector T cell subsets there may be and to what degree their characteristics are fixed or flexible. Here we show that transforming growth factor-beta, a cytokine at the center of the differentiation of IL-17-producing T helper cells and inducible regulatory T cells, 'reprograms' T helper type 2 cells to lose their characteristic profile and switch to IL-9 secretion or, in combination with IL-4, drives the differentiation of 'T-H-9' cells directly. Thus, transforming growth factor-beta constitutes a regulatory 'switch' that in combination with other cytokines can 'reprogram' effector T cell differentiation along different pathways.

引用

页码：1341 / 1346

页数：6

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