Magnetic susceptibility reduction method for magnetically labeled immunoassay

被引：119

作者：

Hong, Chin-Yih

Wu, C. C.

Chiu, Y. C.

Yang, S. Y.

Horng, H. E. ^{[1
]}

Yang, H. C.

机构：

[1] Natl Taiwan Normal Univ, Inst Electroopt Sci & Technol, Taipei 116, Taiwan

[2] Natl Taiwan Normal Univ, Dept Phys, Taipei 116, Taiwan

[3] Da Yeh Univ, Dept Mech & Automat Engn, Changhua 515, Taiwan

[4] Natl Taiwan Univ, Coll Med, Dept Primary Care Med, Taipei 106, Taiwan

[5] Natl Taiwan Univ, Coll Med, Dept Internal Med, Taipei 106, Taiwan

[6] Natl Taiwan Univ, Dept Phys, Taipei 106, Taiwan

来源：

APPLIED PHYSICS LETTERS | 2006年 / 88卷 / 21期

关键词：

D O I：

10.1063/1.2206557

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

In addition to synthesizing biofunctionalized magnetic nanopaticles for the purpose of magnetically labeling biomolecules, a system to measure the ac magnetic susceptibility of the labeled sample was developed. When a targeted biomolecule was mixed with magnetic fluid possessing biofunctionalized magnetic nanoparticles, portions of magnetic nanoparticles agglomerated to form clusters due to the association with the targeted biomolecule. Due to the formation of magnetic clusters, the measured ac magnetic susceptibility reduced. The relationship between the mixed-frequency ac magnetic susceptibility reduction and the amount of the detected biomolecule was established. (c) 2006 American Institute of Physics.

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页数：3

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