Determination of the binding reaction between avidin and biotin by relaxation measurements of magnetic nanoparticles

被引：127

作者：

Kötitz, R

Weitschies, W

Trahms, L

Brewer, W

Semmler, W

机构：

[1] Free Univ Berlin, Inst Diagnost Forsch GmbH, D-14050 Berlin, Germany

[2] Phys Tech Bundesanstalt, D-10587 Berlin, Germany

[3] Free Univ Berlin, D-14195 Berlin, Germany

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 1999年 / 194卷 / 1-3期

关键词：

biological binding reaction; Brownian relaxation; Neel relaxation;

D O I：

10.1016/S0304-8853(98)00580-0

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The binding between avidin and biotinylated magnetic iron oxide nanoparticles can be monitored by means of magnetic relaxation measurements. The resultant signal, caused by particle aggregates, has Brownian and Neel components. The time constant and amplitude of Brownian relaxation were determined by a fit algorithm which also yielded Neel amplitudes proportional to the avidin content of the samples. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：62 / 68

页数：7

共 9 条

[1] Irreversible relaxation behaviour of a general class of magnetic systems [J].