Antibody neutralization of HIV-1

被引：84

作者：

Poignard, P ^{[1
]}

Klasse, PJ ^{[1
]}

Sattentau, QJ ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL,MRC,MOLEC CELL BIOL LAB,LONDON WC1E 6BT,ENGLAND

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 05期

关键词：

D O I：

10.1016/0167-5699(96)10007-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutralizing antibodies are a major component of host defense against viruses, and appear to be particularly important in limiting the spread of cell-free virus. Results from vaccine trials in animal models suggest that these antibodies may contribute to protection against human immunodeficiency virus (HIV) infection. Here, Pascal Poignard and colleagues discuss recent developments in this area, with particular emphasis on the measurement, specificity and mechanism of the antibody response, nod ifs significance for vaccine production.

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页码：239 / 246

页数：8

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