Crystal nucleation for a model of globular proteins

被引：35

作者：

Shiryayev, A ^{[1
]}

Gunton, JD ^{[1
]}

机构：

[1] Lehigh Univ, Dept Phys, Bethlehem, PA 18015 USA

来源：

JOURNAL OF CHEMICAL PHYSICS | 2004年 / 120卷 / 17期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1063/1.1695321

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A continuum model of globular proteins proposed by Talanquer and Oxtoby [J. Chem. Phys. 109, 223 (1998)] is investigated numerically, with particular emphasis on the region near the metastable fluid-fluid coexistence curve. Classical nucleation theory is shown to be invalid not only in the vicinity of the metastable critical point but also close to the liquidus line. An approximate analytic solution is also presented for the shape and properties of the nucleating crystal droplet. (C) 2004 American Institute of Physics.

引用

收藏

页码：8318 / 8326

页数：9

相关论文

共 12 条

[1] Are nucleation kinetics of protein crystals similar to those of liquid droplets? [J].

Galkin, O ;

Vekilov, PG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (01) :156-163

[2] Direct determination of the nucleation rates of protein crystals [J].

Galkin, O ;

Vekilov, PG .

JOURNAL OF PHYSICAL CHEMISTRY B, 1999, 103 (49) :10965-10971

[3] PREDICTING PROTEIN CRYSTALLIZATION FROM A DILUTE-SOLUTION PROPERTY [J].

GEORGE, A ;

WILSON, WW .

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1994, 50 :361-365

[4] ON THE RELATION BETWEEN NUCLEATION WORK, NUCLEUS SIZE, AND NUCLEATION RATE [J].

KASHCHIEV, D .

JOURNAL OF CHEMICAL PHYSICS, 1982, 76 (10) :5098-5102

[5] STATISTICAL THEORY OF DECAY OF METASTABLE STATES [J].

LANGER, JS .

ANNALS OF PHYSICS, 1969, 54 (02) :258-&

[6] Phase behavior of small attractive colloidal particles [J].

Rosenbaum, D ;

Zamora, PC ;

Zukoski, CF .

PHYSICAL REVIEW LETTERS, 1996, 76 (01) :150-153

[7] Scaling theory for the free-energy barrier to homogeneous nucleation of a noncritical phase near a critical point [J].

Sear, RP .

JOURNAL OF CHEMICAL PHYSICS, 2002, 116 (07) :2922-2927

[8] Nucleation of a noncritical phase in a fluid near a critical point [J].

Sear, RP .

JOURNAL OF CHEMICAL PHYSICS, 2001, 114 (07) :3170-3173

[9] Crystal nucleation in the presence of a metastable critical point [J].

Talanquer, V ;

Oxtoby, DW .

JOURNAL OF CHEMICAL PHYSICS, 1998, 109 (01) :223-227

[10] Enhancement of protein crystal nucleation by critical density fluctuations [J].

tenWolde, PR ;

Frenkel, D .

SCIENCE, 1997, 277 (5334) :1975-1978