Acetaldehyde-mediated collagen regulation in hepatic stellate cells

被引：32

作者：

Greenwel, P ^{[1
]}

机构：

[1] CUNY Mt Sinai Sch Med, Dept Dev & Mol Biol, New York, NY 10029 USA

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1999年 / 23卷 / 05期

关键词：

ethanol metabolism; liver; fibrosis; cirrhosis;

D O I：

10.1097/00000374-199905000-00025

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Alcohol-induced liver cirrhosis is one of the major causes of death worldwide. Strong evidence has established that ethanol's first metabolite, acetaldehyde, is highly fibrogenic and enhances the deposition of many extracellular matrix components by hepatic stellate cells. This article reviews our current knowledge of the molecular mechanisms whereby acetaldehyde induces these activities, with particular emphasis on those related to the upregulation of type I collagen.

引用

页码：930 / 933

页数：4

共 36 条

[1] EFFECTS OF ACETALDEHYDE ON NUCLEAR-PROTEIN BINDING TO THE NUCLEAR FACTOR-I CONSENSUS SEQUENCE IN THE ALPHA(2)(I) COLLAGEN PROMOTER
ANANIA, FA
POTTER, JJ
RENNIETANKERSLEY, L
MEZEY, E
[J]. HEPATOLOGY, 1995, 21 (06) : 1640 - 1648
[2] Activation by acetaldehyde of the promoter of the mouse alpha(2)(I) collagen gene when transfected into rat activated stellate cells
Anania, FA
Potter, JJ
RennieTankersley, L
Mezey, E
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1996, 331 (02) : 187 - 193
[3] TRANSFORMING GROWTH-FACTOR-BETA IN DISEASE - THE DARK SIDE OF TISSUE-REPAIR
BORDER, WA
RUOSLAHTI, E
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (01) : 1 - 7
[4] BRENNER DA, 1987, J BIOL CHEM, V262, P17690
[5] ACETALDEHYDE INCREASES PROCOLLAGEN TYPE-I AND FIBRONECTIN GENE-TRANSCRIPTION IN CULTURED RAT FAT-STORING CELLS THROUGH A PROTEIN-SYNTHESIS DEPENDENT MECHANISM
CASINI, A
CUNNINGHAM, M
ROJKIND, M
LIEBER, CS
[J]. HEPATOLOGY, 1991, 13 (04) : 758 - 765
[6] CASINI A, 1994, ALCOHOL ALCOHOLISM, V29, P303
[7] ACETALDEHYDE REGULATES THE GENE-EXPRESSION OF MATRIX-METALLOPROTEINASE-1 AND MATRIX-METALLOPROTEINASE-2 IN HUMAN FAT-STORING CELLS
CASINI, A
CENI, E
SALZANO, R
MILANI, S
SCHUPPAN, D
SURRENTI, C
[J]. LIFE SCIENCES, 1994, 55 (17) : 1311 - 1316
[8] Ethanol induces the expression of α1(I) procollagen mRNA in a co-culture system containing a liver stellate cell-line and freshly isolated hepatocytes
Fontana, L
Jerez, D
Rojas-Valencia, L
Solís-Herruzo, JA
Greenwel, P
Rojkind, M
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1997, 1362 (2-3): : 135 - 144
[9] FRIEDMAN SL, 1993, NEW ENGL J MED, V328, P1828
[10] Sp1 is required for the early response of alpha 2(I) collagen to transforming growth factor-beta 1
Greenwel, P
Inagaki, Y
Hu, W
Walsh, M
Ramirez, F
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (32) : 19738 - 19745

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