Acetaldehyde-mediated collagen regulation in hepatic stellate cells

被引：33

作者：

Greenwel, P ^{[1
]}

机构：

[1] CUNY Mt Sinai Sch Med, Dept Dev & Mol Biol, New York, NY 10029 USA

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1999年 / 23卷 / 05期

关键词：

ethanol metabolism; liver; fibrosis; cirrhosis;

D O I：

10.1097/00000374-199905000-00025

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Alcohol-induced liver cirrhosis is one of the major causes of death worldwide. Strong evidence has established that ethanol's first metabolite, acetaldehyde, is highly fibrogenic and enhances the deposition of many extracellular matrix components by hepatic stellate cells. This article reviews our current knowledge of the molecular mechanisms whereby acetaldehyde induces these activities, with particular emphasis on those related to the upregulation of type I collagen.

引用

页码：930 / 933

页数：4

共 36 条

[31]

RISTINIEMI J, 1989, J BIOL CHEM, V264, P2164

[32]

ROJKIND M, 1993, ADV VET SCI COMP MED, V37, P333

[33]

ROJKIND M, 1988, LIVER BIOL PATHOBIOL, P1269

[34] A NUCLEAR FACTOR-I BINDING-SITE MEDIATES THE TRANSCRIPTIONAL ACTIVATION OF A TYPE-1 COLLAGEN PROMOTER BY TRANSFORMING GROWTH FACTOR-BETA [J].

ROSSI, P ;

KARSENTY, G ;

ROBERTS, AB ;

ROCHE, NS ;

SPORN, MB ;

DECROMBRUGGHE, B .

CELL, 1988, 52 (03) :405-414

[35] EXPERIMENTAL-MODELS OF HEPATIC-FIBROSIS - A REVIEW [J].

TSUKAMOTO, H ;

MATSUOKA, M ;

FRENCH, SW .

SEMINARS IN LIVER DISEASE, 1990, 10 (01) :56-65

[36] OXIDATIVE STRESS, ANTIOXIDANTS, AND ALCOHOLIC LIVER FIBROGENESIS [J].

TSUKAMOTO, H .

ALCOHOL, 1993, 10 (06) :465-467

← 1 2 3 4 →