Synthesis of tricyclic pyridones by radical cyclization

被引：49

作者：

Nadin, A ^{[1
]}

Harrison, T ^{[1
]}

机构：

[1] Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Res Lab, Dept Med Chem, Harlow CM20 2QR, Essex, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(99)00652-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and novel route for the synthesis of tricyclic pyridones by 5-, 6- and 7-exo-trig radical cyclization is described. The use of Pd-catalyzed cross-coupling reactions to introduce functionality at the 5-position of a pyridone is also presented. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：4073 / 4076

页数：4

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