Functional anatomy of intrinsic alertness:: evidence for a fronto-parietal-thalamic-brainstem network in the right hemisphere

被引：357

作者：

Sturm, W ^{[1
]}

de Simone, A

Krause, BJ

Specht, K

Hesselmann, V

Radermacher, I

Herzog, H

Tellmann, L

Müller-Gärtner, HW

Willmes, K

机构：

[1] Rhein Westfal TH Aachen, Neurol Neuropsychol Clin, D-5100 Aachen, Germany

[2] Heinrich Heine Univ Hosp, Dept Nucl Med, Dusseldorf, Germany

[3] Res Ctr Julich, Inst Med, Julich, Germany

来源：

NEUROPSYCHOLOGIA | 1999年 / 37卷 / 07期

关键词：

intrinsic alertness; sustained attention; RT measures; PET-functional imaging;

D O I：

10.1016/S0028-3932(98)00141-9

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Alertness, the most basic intensity aspect of attention, probably is a prerequisite for the more complex and capacity demanding domains of attention selectivity. Behaviorally, intrinsic alertness represents the internal (cognitive) control of wakefulness and arousal; typical tasks to assess optimal levels of intrinsic alertness are simple reaction time measurements without preceding warning stimuli. Up until now only parts of the cerebral network subserving alertness have been revealed in animal, lesion, and functional imaging studies. Here, in a O-15-butanol PET activation study in 15 right-handed young healthy male volunteers for this basic attention function we found an extended right hemisphere network including frontal (anterior cingulate-dorsolateral cortical)-inferior parietal-thalamic (pulvinar and possibly the reticular nucleus) and brainstem (ponto-mesencephalic tegmentum, possibly involving the locus coeruleus) structures, when subjects waited for and rapidly responded to a centrally presented white dot by pressing a response key with the right-hand thumb. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：797 / 805

页数：9

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