Silver-Catalyzed Hydrotrifluoromethylation of Unactivated Alkenes with CF3SiMe3

被引：249

作者：

Wu, Xinyue ^{[1
]}

Chu, Lingling ^{[1
]}

Qing, Feng-Ling ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 08期

基金：

中国国家自然科学基金;

关键词：

fluorine; homogeneous catalysis; radical reactions; silver; synthetic methods; PD(II)-CATALYZED ORTHO-TRIFLUOROMETHYLATION; COPPER-MEDIATED TRIFLUOROMETHYLATION; ARYL BORONIC ACIDS; OXIDATIVE TRIFLUOROMETHYLATION; ROOM-TEMPERATURE; BOND-FORMATION; ALLYLIC TRIFLUOROMETHYLATION; REDUCTIVE ELIMINATION; ARYLBORONIC ACIDS; TERMINAL ALKENES;

D O I：

10.1002/anie.201208971

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A silver bullet: The title reaction results in selective formation of trifluoromethylated alkanes, and is in contrast to the previously reported transition-metal-catalyzed trifluoromethylation of olefins to generate a series of trifluoromethylated allylic compounds. Preliminary mechanistic investigations indicate that the current hydrotrifluoromethylation proceeds through a pathway involving a CF3 radical species. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2198 / 2202

页数：5

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