Clinical and neuropathological correlates of apolipoprotein E genotype in Alzheimer's disease - Window on molecular epidemiology

被引：22

作者：

Hyman, BT ^{[1
]}

GomezIsla, T ^{[1
]}

West, H ^{[1
]}

Briggs, M ^{[1
]}

Chung, H ^{[1
]}

Growdon, JH ^{[1
]}

Rebeck, GW ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA 02114

来源：

NEUROBIOLOGY OF ALZHEIMER'S DISEASE | 1996年 / 777卷

关键词：

D O I：

10.1111/j.1749-6632.1996.tb34414.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inheritance of the apolipoprotein E (apo E) epsilon 4 allele has recently been found to be associated with Alzheimer's disease. We have studied the clinical and neuropathological correlates of apolipoprotein E genotype in a large group of Alzheimer's patients. The primary influence on clinical presentation is a shift towards earlier age of onset in individuals who have the apo E epsilon 4 gene: no change in clinical course was observed. In neuropathological studies, we find that the major influence of apo E epsilon 4 is on increased A beta deposition. These results led to a model of the biological interaction between the apo E protein and Alzheimer's disease.

引用

页码：158 / 165

页数：8

共 27 条

[1] NEUROFIBRILLARY TANGLES BUT NOT SENILE PLAQUES PARALLEL DURATION AND SEVERITY OF ALZHEIMERS-DISEASE
ARRIAGADA, PV
GROWDON, JH
HEDLEYWHYTE, ET
HYMAN, BT
[J]. NEUROLOGY, 1992, 42 (03) : 631 - 639
[2] PROTECTIVE EFFECT OF APOLIPOPROTEIN-E TYPE-2 ALLELE FOR LATE-ONSET ALZHEIMER-DISEASE
CORDER, EH
SAUNDERS, AM
RISCH, NJ
STRITTMATTER, WJ
SCHMECHEL, DE
GASKELL, PC
RIMMLER, JB
LOCKE, PA
CONNEALLY, PM
SCHMADER, KE
SMALL, GW
ROSES, AD
HAINES, JL
PERICAKVANCE, MA
[J]. NATURE GENETICS, 1994, 7 (02) : 180 - 184
[3] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES
CORDER, EH
SAUNDERS, AM
STRITTMATTER, WJ
SCHMECHEL, DE
GASKELL, PC
SMALL, GW
ROSES, AD
HAINES, JL
PERICAKVANCE, MA
[J]. SCIENCE, 1993, 261 (5123) : 921 - 923
[4] GOMEZISLA T, 1995, IN PRESS ANN NEUROL
[5] APOLIPOPROTEIN-E EPSILON-4 AND CEREBRAL-HEMORRHAGE ASSOCIATED WITH AMYLOID ANGIOPATHY
GREENBERG, SM
REBECK, GW
VONSATTEL, JPG
GOMEZISLA, T
HYMAN, BT
[J]. ANNALS OF NEUROLOGY, 1995, 38 (02) : 254 - 259
[6] APOLIPOPROTEIN-E IS LOCALIZED TO THE CYTOPLASM OF HUMAN CORTICAL-NEURONS - A LIGHT AND ELECTRON-MICROSCOPIC STUDY
HAN, SH
EINSTEIN, G
WEISGRABER, KH
STRITTMATTER, WJ
SAUNDERS, AM
PERICAKVANCE, M
ROSES, AD
SCHMECHEL, DE
[J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1994, 53 (05) : 535 - 544
[7] Herz Joachim, 1993, Current Opinion in Lipidology, V4, P107, DOI 10.1097/00041433-199304000-00006
[8] QUANTITATIVE-ANALYSIS OF SENILE PLAQUES IN ALZHEIMER-DISEASE - OBSERVATION OF LOG-NORMAL SIZE DISTRIBUTION AND MOLECULAR EPIDEMIOLOGY OF DIFFERENCES ASSOCIATED WITH APOLIPOPROTEIN-E GENOTYPE AND TRISOMY-21 (DOWN-SYNDROME)
HYMAN, BT
WEST, HL
REBECK, GW
BULDYREV, SV
MANTEGNA, RN
UKLEJA, M
HAVLIN, S
STANLEY, HE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (08) : 3586 - 3590
[9] LADU MJ, 1994, J BIOL CHEM, V269, P23403
[10] MA Y, 1994, NATURE, V372, P92

← 1 2 3 →