Predictions of protein-RNA interactions

被引:14
作者
Cirillo, Davide
Agostini, Federico
Gaetano Tartaglia, Gian [1 ]
机构
[1] CRG, Barcelona 08003, Spain
关键词
BINDING-SITES; ESCHERICHIA-COLI; SECONDARY-STRUCTURE; NONCODING RNAS; GENE CSRA; COMPLEXES; RECOGNITION; SVM;
D O I
10.1002/wcms.1119
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Ribonucleoprotein interactions play important roles in a wide variety of cellular processes, ranging from transcriptional and posttranscriptional regulation of gene expression to host defense against pathogens. High throughput experiments to identify RNA-protein interactions provide information about the complexity of interaction networks, but require time and considerable efforts. Thus, there is need for reliable computational methods for predicting ribonucleoprotein interactions. In this review, we discuss a number of approaches that have been developed to predict the ability of proteins and RNA molecules to associate. (C) 2012 John Wiley & Sons, Ltd.
引用
收藏
页码:161 / 175
页数:15
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