Recent advances in xenotransplantation

被引:45
作者
Sandrin, MS [1 ]
McKenzie, IFC [1 ]
机构
[1] Repatriat Med Ctr, Heidelberg, Vic 3084, Australia
基金
英国医学研究理事会;
关键词
D O I
10.1016/S0952-7915(99)00011-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The major barrier to clinically successful pig-to-human xenotransplantation is antibody- and complement-dependent hyperacute rejection, known to be due to host antiGal alpha(1,3)Gal antibodies. Strategies aimed at eliminating hyperacute rejection involve transgenic approaches to eliminate or reduce expression of Gal alpha(1,3)Gal or to reduce complement activation; some of these are now in clinical trials in primates. Another important role of Gal alpha(1,3)Gal that is becoming more evident is in antibody-dependent and -independent xenograft rejection that is mediated by natural killer cells and monocytes.
引用
收藏
页码:527 / 531
页数:5
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