Delayed xenograft rejection

被引：304

作者：

Bach, FH

Winkler, H

Ferran, C

Hancock, WW

Robson, SC

机构：

[1] Sandoz Center for Immunobiology, Harvard Medical School, New England Deaconess Hospital, Boston, MA 02215

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 08期

关键词：

D O I：

10.1016/0167-5699(96)10024-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite considerable progress in understanding the mechanisms of discordant xenograft rejection, and overcoming hyperacute rejection through targeting of complement or antibody, vascularized xenografts are typically rejected within days. Here, Fritz Bach and colleagues discuss the importance of endothelial cell activation, platelet aggregation and other aspects of thrombosis, as well as the contribution of host natural killer cell and monocyte activation in overcoming this next barrier to prolonged xenograft survival.

引用

页码：379 / 384

页数：6

共 62 条

[1]

BACH FH, 1995, TRANSPLANT P, V27, P77

[2]

BACH FH, 1992, TRANSPLANT P, V24, P49

[3]

BACH FH, 1991, TRANSPL P, V23, P205

[4] ENDOTHELIAL-CELL ACTIVATION AND THROMBOREGULATION DURING XENOGRAFT REJECTION [J].

BACH, FH ;

ROBSON, SC ;

FERRAN, C ;

WINKLER, H ;

MILLAN, MT ;

STUHLMEIER, KM ;

VANHOVE, B ;

BLAKELY, ML ;

VANDERWERF, WJ ;

HOFER, E ;

DEMARTIN, R ;

HANCOCK, WW .

IMMUNOLOGICAL REVIEWS, 1994, 141 :5-30

[5] BARRIERS TO XENOTRANSPLANTATION [J].

BACH, FH ;

ROBSON, SC ;

WINKLER, H ;

FERRAN, C ;

STUHLMEIER, KM ;

WRIGHTON, CJ ;

HANCOCK, WW .

NATURE MEDICINE, 1995, 1 (09) :869-873

[6]

Bach FH, 1996, CLIN TRANSPLANT, V10, P124

[7]

BACH FH, 1993, TRANSPLANT P, V25, P25

[8]

BAEUERLE PA, 1994, ANNU REV IMMUNOL, V12, P141, DOI 10.1146/annurev.immunol.12.1.141

[9] COMPLEMENT IN ORGAN-TRANSPLANTATION - CONTRIBUTIONS TO INFLAMMATION, INJURY, AND REJECTION [J].

BALDWIN, WM ;

PRUITT, SK ;

BRAUER, RB ;

DAHA, MR ;

SANFILIPPO, F .

TRANSPLANTATION, 1995, 59 (06) :797-808

[10] ACTIVATION OF INTRAGRAFT ENDOTHELIAL AND MONONUCLEAR-CELLS DURING DISCORDANT XENOGRAFT REJECTION [J].

BLAKELY, ML ;

VANDERWERF, WJ ;

BERNDT, MC ;

DALMASSO, AP ;

BACH, FH ;

HANCOCK, WW .

TRANSPLANTATION, 1994, 58 (10) :1059-1066

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