Delayed xenograft rejection

被引:304
作者
Bach, FH
Winkler, H
Ferran, C
Hancock, WW
Robson, SC
机构
[1] Sandoz Center for Immunobiology, Harvard Medical School, New England Deaconess Hospital, Boston, MA 02215
来源
IMMUNOLOGY TODAY | 1996年 / 17卷 / 08期
关键词
D O I
10.1016/0167-5699(96)10024-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Despite considerable progress in understanding the mechanisms of discordant xenograft rejection, and overcoming hyperacute rejection through targeting of complement or antibody, vascularized xenografts are typically rejected within days. Here, Fritz Bach and colleagues discuss the importance of endothelial cell activation, platelet aggregation and other aspects of thrombosis, as well as the contribution of host natural killer cell and monocyte activation in overcoming this next barrier to prolonged xenograft survival.
引用
收藏
页码:379 / 384
页数:6
相关论文
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