Apoptosis - Key to the mitochondrial gate

被引：80

作者：

Martinou, JC ^{[1
]}

机构：

[1] Serono Pharmaceut Res Inst, CH-1228 Geneva, Switzerland

来源：

NATURE | 1999年 / 399卷 / 6735期

关键词：

D O I：

10.1038/20804

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When cytochromec, which is normally localized in the mitochondria, escapes into the cytosol, it helps to activate the caspases (killer proteases) leading to cell death. New evidence indicates that the key to release of cytochrome c is the so-called voltage-dependent ion channel. Proteins that promote apoptosis seem to bind to this channel, causing it to change shape so that cytochrome ccan pass through.

引用

页码：411 / 412

页数：2

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