Human embryonic genes re-expressed in cancer cells

被引：277

作者：

Monk, M ^{[1
]}

Holding, C ^{[1
]}

机构：

[1] Inst Child Hlth, Mol Embryol Unit, London WC1N 1EH, England

来源：

ONCOGENE | 2001年 / 20卷 / 56期

基金：

英国医学研究理事会;

关键词：

human developmental genes; human preimplantation embryo; OCT4; embryo/cancer genes; cancer gene expression;

D O I：

10.1038/sj.onc.1205088

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human preimplantation embryonic cells are similar in phenotype to cancer cells. Both types of cell undergo deprogramming to a proliferative stem cell state and become potentially immortal and invasive. To investigate the hypothesis that embryonic genes are re-expressed in cancer cells, we prepare amplified cDNA from human individual preimplantation embryos and isolate embryo-specific sequences. We show that three novel embryonic genes, and also the known gene, OCT4, are expressed in human tumours but not expressed in normal somatic tissues. Genes specific to this unique phase of the human life cycle and not expressed in somatic cells may have greater potential for targeting in cancer treatment.

引用

页码：8085 / 8091

页数：7

共 38 条

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