The AT2 receptor:: fact, fancy and fantasy

The angiotensin AT(2) receptor subtype was recently cloned and pharmacologically characterized but its function still remains elusive and controversial. It is a member of the G-protein coupled receptor superfamily with a minimal sequence homology with the AT(1) receptor. responsible for the known effect of angiotensin II. The AT(2) receptor displays a totally different signaling mechanisms from the AT(1) receptor and involves various phosphatases. It is expressed at low density in adult tissues but up-regulated in pathological circumstances. Clearly, the AT(2) receptor has antiproliferative properties and therefore opposes the growth promoting effect linked to the AT(1) receptor stimulation. It is also reported that the AT(2) receptor regulates ionic fluxes, affects differentiation and nerve regeneration, has anti-angiogenic and anti-fibrotic properties and stimulates apoptosis. However, the results, although suggestive, are sometimes equivocal. Obviously, the AT(2) receptor plays a role in the pathogenesis and remodeling of cardiovascular and renal diseases. A more extensive knowledge of the AT(2) receptor could therefore contribute to the understanding of the clincial beneficial effects of the AT(1) receptor antagonists. (C) 1999 Elsevier Science B.V. All rights reserved.