Diastereocontrolled synthesis of an enantiopure 4,4-disubstituted cyclohex-2-en-ol: a new route to (+)-quebrachamine

被引：9

作者：

Fujimura, T ^{[1
]}

Nakashima, H ^{[1
]}

Sakagami, H ^{[1
]}

Taniguchi, T ^{[1
]}

Ogasawara, K ^{[1
]}

机构：

[1] Tohoku Univ, Inst Pharmaceut, Sendai, Miyagi 9808578, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 01期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/S0040-4039(01)02075-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A diastereoselective route to an enantiopure 4,4-disubstituted cyclohex-2-en-1-ol has been developed using the synthetic equivalent of chiral 4-hydroxycyclohex-2-en-1-one. Its stereochemistry has been determined by its transformation into the Aspidosperma indole alkaloid (+)-quebrachamine. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：97 / 99

页数：3

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