CD28/CTLA-4 and CD80/CD86 families - Signaling and function

被引：153

作者：

Slavik, JM

Hutchcroft, JE

Bierer, BE

机构：

[1] NHLBI, NIH, Bethesda, MD 20892 USA

[2] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

[4] Purdue Univ, Dept Biochem, W Lafayette, IN 47907 USA

来源：

IMMUNOLOGIC RESEARCH | 1999年 / 19卷 / 01期

基金：

美国国家卫生研究院;

关键词：

T lymphocytes; signal transduction; cell-surface molecules; costimulatory molecules;

D O I：

10.1007/BF02786473

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cell stimulation in the absence of a second, costimulatory signal can lead to anergy or the induction of cell death. CD28 is a major T cell costimulatory receptor, the coengagement of which can prevent anergy and cell death. The CD28 receptor is a member of a complex family of polypeptides that includes at least two receptors and two ligands. Cytotoxic lymphocyte-associated molecule-4 (CTLA-4, CD152) is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). This article reviews the CD28/CTLA4 and CD80/CD86 families, and outlines the functional outcomes an biochemical signaling pathways recruited after CD28 ligation.

引用

页码：1 / 24

页数：24

共 199 条

[101]

LEDBETTER JA, 1992, ADV EXP MED BIOL, V323, P23

[102]

LEDBETTER JA, 1990, BLOOD, V75, P1531

[103]

LEDBETTER JA, 1986, J IMMUNOL, V137, P3299

[104] PH domains: Diverse sequences with a common fold recruit signaling molecules to the cell surface [J].