Helper T cell diversity and plasticity

被引：231

作者：

Nakayamada, Shingo ^{[1
]}

Takahashi, Hayato ^{[1
]}

Kanno, Yuka ^{[1
]}

O'Shea, John J. ^{[1
]}

机构：

[1] NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 03期

关键词：

GERMINAL CENTER RESPONSE; LINEAGE COMMITMENT; IMMUNE-RESPONSES; INTERFERON-GAMMA; TH1; RESPONSES; DIFFERENTIATION; TRANSCRIPTION; DISTINCT; INFLAMMATION; BET;

D O I：

10.1016/j.coi.2012.01.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD4(+) helper T cells play crucial roles for host defense and immune-mediated disease by their ability to differentiate into specialized subsets. These subsets attain restricted patterns of cytokine secretion and specific expression of master transcription factors in response to microbial pathogens. Classically, the various helper CD4(+) T cell subsets have been viewed as terminally differentiated lineages with limited flexibility. However, following the recognition of new subsets, there is increased recognition of plasticity. In this review, we highlight recent advances that pertain to this topic and the mechanisms that contribute to helper CD4(+) T cell differentiation and plasticity.

引用

页码：297 / 302

页数：6

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