TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors

被引：205

作者：

Arts, Rob J. W.

Joosten, Leo A. B.

van der Meer, Jos W. M.

Netea, Mihai G.

机构：

[1] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands

[2] Nijmegen Inst Infect Inflammat & Immun N4i, Nijmegen, Netherlands

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2013年 / 93卷 / 02期

关键词：

TLR; NLR; DAP12; signaling cascade; myeloid cells; MYELOID CELLS-1 TREM-1; CUTTING EDGE; INFLAMMATORY RESPONSES; NEGATIVE REGULATOR; PROMOTES RESISTANCE; EXPRESSION PATTERNS; INNATE IMMUNITY; HUMAN MONOCYTES; HOST-DEFENSE; LIPID RAFTS;

D O I：

10.1189/jlb.0312145

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

TREM-1 is an important signaling receptor expressed on neutrophils and monocytes that plays an important role in systemic infections. Here, we review the intracellular signaling pathways that mediate the immunological effects of TREM-1. Because of the absence of signaling motifs, TREM-1 constitutively associates with DAP12 for induction of intracellular signals. After phosphorylation of DAP12, production of chemokines and cytokines is induced. Moreover, TREM-1 also modulates signaling pathways induced by known classes of PRRs, such as TLRs and NLRs. The exact mechanisms through which TREM-1 influences TLR and NLR pathways are still largely elusive. J. Leukoc. Biol. 93: 209-215; 2013.

引用

收藏

页码：209 / 215

页数：7

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