Reactivity of carbon nanotubes: Free radical generation or scavenging activity?

被引:253
作者
Fenoglio, I
Tomatis, M
Lison, D
Muller, J
Fonseca, A
Nagy, JB
Fubini, B [1 ]
机构
[1] Univ Turin, Ctr Excellence Nanostructured Interfaces & Surfac, Dipartimento Chim Inorgan Chem Fis & Chim Mat, I-10125 Turin, Italy
[2] Univ Turin, Ctr Excellence Nanostructured Interfaces & Surfac, Interdept Ctr G Scansetti Studies Asbestos & Othe, I-10125 Turin, Italy
[3] Catholic Univ Louvain, Ind Toxicol & Occupat Med Unit, B-1200 Brussels, Belgium
[4] Fac Univ Notre Dame Paix, Lab Nucl Magnet Resonance, B-5000 Namur, Belgium
关键词
toxicity; ROS; scavenging; multiwall carbon nanotubes; free radicals;
D O I
10.1016/j.freeradbiomed.2005.11.010
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Carbon nanotubes (CNTs) currently attract intense research efforts because of their unique properties which make them suitable for many industrial applications. When inhaled, CNTs constitute a possible hazard to human health. Several studies have shown that when instilled in the lung of experimental animals, CNTs induced an inflammatory and fibrotic response similar to that caused by other toxic particles which might be the result of oxidative stress caused by particle- and/or cell-derived free radicals. There is, however, no direct experimental evidence of a capacity of carbon nanotubes to generate directly free radicals. Here we report that multiwall carbon nanotubes (MWCNT) in aqueous suspension do not generate oxygen or carbon-centered free radicals in the presence of H2O2 or formate, respectively, as detected with the spin-trapping technique. Conversely, we observed that, when in contact with an external Source of hydroxyl or superoxide radicals, MWCNT exhibit a remarkable radical scavenging capacity. It is therefore possible that the inflammatory reaction reported in vivo must be ascribed to MWCNT features other than particle-derived free radical generation. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:1227 / 1233
页数:7
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