Effect of a herbal protein, CI-1, isolated from Cajanus indicus on immune response of control and stressed mice

被引：8

作者：

Datta, S ^{[1
]}

Sinha, S ^{[1
]}

Bhattacharyya, P ^{[1
]}

机构：

[1] Bose Inst, Dept Chem, Kolkata 700009, W Bengal, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1999年 / 67卷 / 03期

关键词：

immunomodulation; humoral immune response; cell-mediated immune response; herbal protein; Cajanus indicus; stress; immunopotentiation; immune system; delayed type hypersitivity; anaphylactic shock;

D O I：

10.1016/S0378-8741(99)00046-X

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The effect of a herbal protein, CI-1, purified from the leaves of Cajanus indicus was evaluated as a probable immunomodulator on immune response in control and stressed mice. In mice, sensitized with sheep red blood cells (SRBC), CI-1 enhanced IgG level by 28% over control (P < 0.05). Primary and secondary antibody response to SRBC and bovine serum albumin (BSA) were significantly increased in CI-1 treated group. Furthermore CI-1 facilitated the delayed type of hypersensitivity (DTH) response to SRBC in sensitized mice and also enhanced leucocyte and macrophage migration inhibition response in immunized mice. A fewer mice displayed symptoms of anaphylactic shock after CI-1 administration at a dose of 6.0 mg/kg body wt. in BSA sensitized mice. The immediate effect of CI-1 on anaphylactic shock was not seen when 150 mu g of CI-1 was injected in combination with BSA in the shocking injection. These results suggest that CI-1 influences both humoral and cell-mediated immune response. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：259 / 267

页数：9

共 40 条

[11]

Bussing A, 1997, ANTI-CANCER DRUG, V8, pS9, DOI 10.1097/00001813-199704001-00003

[12]

Chopra R. N., 1986, GLOSSARY INDIAN MED, P44

[13]

Datta Sarmistha, 1998, Indian Journal of Experimental Biology, V36, P175

[14]

FARGHALI H, 1984, METHOD FIND EXP CLIN, V6, P449

[15]

Fletcher MA, 1992, Manual of Clinical Laboratory Immunology, V4th, P213

[16]

GHOSH A, 1973, BHARATIYA BANAUSADHI, V2, P332

[17]

HAMES BD, 1981, GEL ELECTROPHORESIS, P1

[18] VIRULENT SALMONELLA-TYPHIMURIUM-INDUCED LYMPHOCYTE DEPLETION AND IMMUNOSUPPRESSION IN CHICKENS [J].

HASSAN, JO ;

CURTISS, R .

INFECTION AND IMMUNITY, 1994, 62 (05) :2027-2036

[19] Fip-vvo, a new fungal immunomodulatory protein isolated from Volvariella volvacea [J].

Hsu, HC ;

Hsu, CI ;

Lin, RH ;

Kao, CL ;

Lin, JY .

BIOCHEMICAL JOURNAL, 1997, 323 :557-565

[20]

HUDSON L, 1989, PRACTICAL IMMUNOLOGY, P230

← 1 2 3 4 →