Cytokines and depression: an analogic approach

被引：36

作者：

Corcos, M ^{[1
]}

Guilbaud, O ^{[1
]}

Hjalmarsson, L ^{[1
]}

Chambry, J ^{[1
]}

Jeammet, P ^{[1
]}

机构：

[1] Inst Mutualiste Montsouris, Dept Adolescent & Young Adult Psychiat, Pr Jeammet, F-75014 Paris, France

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2002年 / 56卷 / 02期

关键词：

cytokines; depression; psychoneuroimmunoendocrinology;

D O I：

10.1016/S0753-3322(01)00156-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

growing body of evidence suggests that major depressive disorders may be accompanied by immune dysfunction and more particularly by an enhanced production of pro-inflammatory cytokines. The possible involvement of cytokines in depressive illness are based upon an analogic model. Pro-inflammatory cytokines are known to induce behavioral effects, and neuro-endocrine and immune activation similar to those observed in depression; these can be alleviated by antidepressant treatment. In this paper, we review research literature on the links between depressive illness and cytokine production and address further questions on this cytokine pathway. Further research is needed to see whether cytokines sustain specific depressive syndromes or whether cytokines induce depressive-like symptoms. 2002 Editions scientifiques et medicales Elsevier SAS.

引用

页码：105 / 110

页数：6

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