Dextromethorphan- and pseudoephedrine-induced agitated psychosis and ataxia: Case report

被引：44

作者：

Roberge, RJ

Hirani, KH

Rowland, PL

Berkeley, R

Krenzelok, EP

机构：

[1] Western Penn Hosp, Dept Emergency Med, Pittsburgh, PA 15224 USA

[2] Western Penn Hosp, Dept Pediat, Pittsburgh, PA 15224 USA

[3] Western Penn Hosp, Internal Med Residency Program, Pittsburgh, PA 15224 USA

[4] Univ Pittsburgh, Sch Med, Affiliated Residency Emergency Med, Pittsburgh, PA USA

[5] Univ Pittsburgh, Sch Med, Dept Pediat, Pittsburgh, PA USA

[6] Univ Pittsburgh, Sch Med, Dept Pharm, Pittsburgh, PA USA

[7] Pittsburgh Poison Ctr, Pittsburgh, PA USA

来源：

JOURNAL OF EMERGENCY MEDICINE | 1999年 / 17卷 / 02期

关键词：

dextromethorphan; pseudoephedrine; toxicity; pediatric;

D O I：

10.1016/S0736-4679(98)00193-0

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Pseudoephedrine and dextromethorphan are therapeutic constituents of numerous commonly used, over-the-counter cough and cold preparations. Although this drug combination is generally considered quite safe if utilized in recommended doses, overmedication or overdose can result in serious neurologic and cardiovascular abnormalities that occasionally can be life-threatening. We present a case of a 2-year-old child who developed hyperirritability, psychosis, and ataxia after being overmedicated with a pseudoephedrine/dextromethorphan combination cough preparation, and discuss probable mechanisms of toxicity and risk factors for adverse events. (C) 1999 Elsevier Science Inc.

引用

页码：285 / 288

页数：4

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