The formation of biodegradable polymeric micelles from newly synthesized poly(aspartic acid)-block-polylactide AB-type diblock copolymers

被引：58

作者：

Arimura, H

Ohya, Y ^{[1
]}

Ouchi, T

机构：

[1] Kansai Univ, Fac Engn, Osaka 5648680, Japan

[2] Kansai Univ, High Technol Res Ctr, Osaka 5648680, Japan

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2004年 / 25卷 / 06期

关键词：

biocompatibility; biodegradable; block copolymers; micelles;

D O I：

10.1002/marc.200300259

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A poly(aspartic acid)-block-polylactide- (PAsp-block-PLA) diblock copolymer was synthesized through the polymerization of beta-benzyl-L-aspartate-N-carboxyanhydride [Asp(OBzl)-NCA] with amino-terminating polylactide (NH2-PLA) as a macroinitiator. The chain length of the PAsp segment could be easily controlled by changing the. monomer/initiator ratio. Dynamic light scattering measurements of PAsp-block-PLA aqueous solutions revealed the formation of polymeric micelles. Changes in the micelles as a function of pH were investigated.

引用

页码：743 / 747

页数：5

共 24 条

[1]

AC Albertsson, 1998, DEGRADABLE POLYM

[2] Preparation of polylactide microspheres having positively or negatively charged surfaces [J].