RETRACTED: G protein-induced trafficking of voltage-dependent calcium channels (Retracted Article)

被引：40

作者：

Tombler, E ^{[1
]}

Cabanilla, NJ ^{[1
]}

Carman, P ^{[1
]}

Permaul, N ^{[1
]}

Hall, JJ ^{[1
]}

Richman, RW ^{[1
]}

Lee, J ^{[1
]}

Rodriguez, J ^{[1
]}

Felsenfeld, DP ^{[1
]}

Hennigan, RF ^{[1
]}

Diversé-Pierluissi, MA ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Pharmacol & Biol Chem, New York, NY 10029 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2006年 / 281卷 / 03期

关键词：

D O I：

10.1074/jbc.M508829200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcium channels are well known targets for inhibition by G protein-coupled receptors, and multiple forms of inhibition have been described. Here we report a novel mechanism for G protein-mediated modulation of neuronal voltage-dependent calcium channels that involves the destabilization and subsequent removal of calcium channels from the plasma membrane. Imaging experiments in living sensory neurons show that, within seconds of receptor activation, calcium channels are cleared from the membrane and sequestered in clathrin-coated vesicles. Disruption of the L1-CAM-ankyrin B complex with the calcium channel mimics transmitter-induced trafficking of the channels, reduces calcium influx, and decreases exocytosis. Our results suggest that G protein-induced removal of plasma membrane calcium channels is a consequence of disrupting channel-cytoskeleton interactions and might represent a novel mechanism of presynaptic inhibition.

引用

页码：1827 / 1839

页数：13

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