共 54 条
Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity
被引:294
作者:

Wilson, NS
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Behrens, GMN
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Lundie, RJ
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Smith, CM
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

论文数: 引用数:
h-index:
机构:

Young, L
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Forehan, SP
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Mount, A
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Steptoe, RJ
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Shortman, KD
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

de Koning-Ward, TF
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Belz, GT
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Carbone, FR
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Crabb, BS
论文数: 0 引用数: 0
h-index: 0
机构:
Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Heath, WR
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

Villadangos, JA
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
机构:
[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
[2] Cooperat Res Ctr Vaccine Technol, Parkville, Vic 3050, Australia
[3] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia
[4] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia
[5] Univ Queensland, Ctr Immunol & Canc Res, Brisbane, Qld 4102, Australia
基金:
英国惠康基金;
关键词:
D O I:
10.1038/ni1300
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
The mechanisms responsible for the immunosuppression associated with sepsis or some chronic blood infections remain poorly understood. Here we show that infection with a malaria parasite (Plasmodium berghei) or simple systemic exposure to bacterial or viral Toll-like receptor ligands inhibited cross-priming. Reduced cross-priming was a consequence of downregulation of cross-presentation by activated dendritic cells due to systemic activation that did not otherwise globally inhibit T cell proliferation. Although activated dendritic cells retained their capacity to present viral antigens via the endogenous major histocompatibility complex class I processing pathway, antiviral responses were greatly impaired in mice exposed to Toll-like receptor ligands. This is consistent with a key function for cross-presentation in antiviral immunity and helps explain the immunosuppressive effects of systemic infection. Moreover, inhibition of cross-presentation was overcome by injection of dendritic cells bearing antigen, which provides a new strategy for generating immunity during immunosuppressive blood infections.
引用
收藏
页码:165 / 172
页数:8
相关论文
共 54 条
[1]
Epidermal viral immunity induced by CD8α+ dendritic cells but not by Langerhans cells
[J].
Allan, RS
;
Smith, CM
;
Belz, GT
;
van Lint, AL
;
Wakim, LM
;
Heath, WR
;
Carbone, FR
.
SCIENCE,
2003, 301 (5641)
:1925-1928

Allan, RS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

Smith, CM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

Belz, GT
论文数: 0 引用数: 0
h-index: 0
机构: Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

van Lint, AL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

Wakim, LM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

Heath, WR
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

Carbone, FR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia
[2]
Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements
[J].
Barnden, MJ
;
Allison, J
;
Heath, WR
;
Carbone, FR
.
IMMUNOLOGY AND CELL BIOLOGY,
1998, 76 (01)
:34-40

Barnden, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Monash Med Sch, Dept Pathol & Immunol, Prahran, Vic 3181, Australia

Allison, J
论文数: 0 引用数: 0
h-index: 0
机构: Monash Med Sch, Dept Pathol & Immunol, Prahran, Vic 3181, Australia

Heath, WR
论文数: 0 引用数: 0
h-index: 0
机构: Monash Med Sch, Dept Pathol & Immunol, Prahran, Vic 3181, Australia

Carbone, FR
论文数: 0 引用数: 0
h-index: 0
机构: Monash Med Sch, Dept Pathol & Immunol, Prahran, Vic 3181, Australia
[3]
Cutting edge:: Conventional CD8α+ dendritic cells are generally involved in priming CTL immunity to viruses
[J].
Belz, GT
;
Smith, CM
;
Eichner, D
;
Shortman, K
;
Karupiah, G
;
Carbone, FR
;
Heath, WK
.
JOURNAL OF IMMUNOLOGY,
2004, 172 (04)
:1996-2000

Belz, GT
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

Smith, CM
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

Eichner, D
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

Shortman, K
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

论文数: 引用数:
h-index:
机构:

Carbone, FR
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

Heath, WK
论文数: 0 引用数: 0
h-index: 0
机构: Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia
[4]
Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo
[J].
Brocker, T
;
Riedinger, M
;
Karjalainen, K
.
JOURNAL OF EXPERIMENTAL MEDICINE,
1997, 185 (03)
:541-550

Brocker, T
论文数: 0 引用数: 0
h-index: 0
机构: Basel Institute for Immunology

Riedinger, M
论文数: 0 引用数: 0
h-index: 0
机构: Basel Institute for Immunology

Karjalainen, K
论文数: 0 引用数: 0
h-index: 0
机构: Basel Institute for Immunology
[5]
Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
[J].
Cella, M
;
Engering, A
;
Pinet, V
;
Pieters, J
;
Lanzavecchia, A
.
NATURE,
1997, 388 (6644)
:782-787

Cella, M
论文数: 0 引用数: 0
h-index: 0
机构:
HOP ST ELOI,IMMUNOL LAB,INSERM,U291,F-34295 MONTPELLIER,FRANCE HOP ST ELOI,IMMUNOL LAB,INSERM,U291,F-34295 MONTPELLIER,FRANCE

Engering, A
论文数: 0 引用数: 0
h-index: 0
机构:
HOP ST ELOI,IMMUNOL LAB,INSERM,U291,F-34295 MONTPELLIER,FRANCE HOP ST ELOI,IMMUNOL LAB,INSERM,U291,F-34295 MONTPELLIER,FRANCE

Pinet, V
论文数: 0 引用数: 0
h-index: 0
机构:
HOP ST ELOI,IMMUNOL LAB,INSERM,U291,F-34295 MONTPELLIER,FRANCE HOP ST ELOI,IMMUNOL LAB,INSERM,U291,F-34295 MONTPELLIER,FRANCE

Pieters, J
论文数: 0 引用数: 0
h-index: 0
机构:
HOP ST ELOI,IMMUNOL LAB,INSERM,U291,F-34295 MONTPELLIER,FRANCE HOP ST ELOI,IMMUNOL LAB,INSERM,U291,F-34295 MONTPELLIER,FRANCE

Lanzavecchia, A
论文数: 0 引用数: 0
h-index: 0
机构:
HOP ST ELOI,IMMUNOL LAB,INSERM,U291,F-34295 MONTPELLIER,FRANCE HOP ST ELOI,IMMUNOL LAB,INSERM,U291,F-34295 MONTPELLIER,FRANCE
[6]
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
[J].
Coban, C
;
Ishii, KJ
;
Kawai, T
;
Hemmi, H
;
Sato, S
;
Uematsu, S
;
Yamamoto, M
;
Takeuchi, O
;
Itagaki, S
;
Kumar, N
;
Horii, T
;
Akira, S
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2005, 201 (01)
:19-25

Coban, C
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, ERATO, JST Agcy, Osaka 5650871, Japan

Ishii, KJ
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, ERATO, JST Agcy, Osaka 5650871, Japan

Kawai, T
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, ERATO, JST Agcy, Osaka 5650871, Japan

Hemmi, H
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, ERATO, JST Agcy, Osaka 5650871, Japan

Sato, S
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, ERATO, JST Agcy, Osaka 5650871, Japan

Uematsu, S
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, ERATO, JST Agcy, Osaka 5650871, Japan

Yamamoto, M
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, ERATO, JST Agcy, Osaka 5650871, Japan

Takeuchi, O
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, ERATO, JST Agcy, Osaka 5650871, Japan

Itagaki, S
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, ERATO, JST Agcy, Osaka 5650871, Japan

Kumar, N
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, ERATO, JST Agcy, Osaka 5650871, Japan

Horii, T
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, ERATO, JST Agcy, Osaka 5650871, Japan

Akira, S
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Univ, ERATO, JST Agcy, Osaka 5650871, Japan Osaka Univ, ERATO, JST Agcy, Osaka 5650871, Japan
[7]
The immunopathogenesis of sepsis
[J].
Cohen, J
.
NATURE,
2002, 420 (6917)
:885-891

Cohen, J
论文数: 0 引用数: 0
h-index: 0
机构:
Brighton & Sussex Med Sch, Brighton BN1 9PH, E Sussex, England Brighton & Sussex Med Sch, Brighton BN1 9PH, E Sussex, England
[8]
Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo
[J].
DeSmedt, T
;
Pajak, B
;
Muraille, E
;
Lespagnard, L
;
Heinen, E
;
DeBaetselier, P
;
Urbain, J
;
Leo, O
;
Moser, M
.
JOURNAL OF EXPERIMENTAL MEDICINE,
1996, 184 (04)
:1413-1424

DeSmedt, T
论文数: 0 引用数: 0
h-index: 0
机构: FREE UNIV BRUSSELS,DEPT BIOL MOL,PHYSIOL ANIM LAB,B-1640 RHODE ST GENESE,BELGIUM

Pajak, B
论文数: 0 引用数: 0
h-index: 0
机构: FREE UNIV BRUSSELS,DEPT BIOL MOL,PHYSIOL ANIM LAB,B-1640 RHODE ST GENESE,BELGIUM

Muraille, E
论文数: 0 引用数: 0
h-index: 0
机构: FREE UNIV BRUSSELS,DEPT BIOL MOL,PHYSIOL ANIM LAB,B-1640 RHODE ST GENESE,BELGIUM

Lespagnard, L
论文数: 0 引用数: 0
h-index: 0
机构: FREE UNIV BRUSSELS,DEPT BIOL MOL,PHYSIOL ANIM LAB,B-1640 RHODE ST GENESE,BELGIUM

Heinen, E
论文数: 0 引用数: 0
h-index: 0
机构: FREE UNIV BRUSSELS,DEPT BIOL MOL,PHYSIOL ANIM LAB,B-1640 RHODE ST GENESE,BELGIUM

DeBaetselier, P
论文数: 0 引用数: 0
h-index: 0
机构: FREE UNIV BRUSSELS,DEPT BIOL MOL,PHYSIOL ANIM LAB,B-1640 RHODE ST GENESE,BELGIUM

Urbain, J
论文数: 0 引用数: 0
h-index: 0
机构: FREE UNIV BRUSSELS,DEPT BIOL MOL,PHYSIOL ANIM LAB,B-1640 RHODE ST GENESE,BELGIUM

Leo, O
论文数: 0 引用数: 0
h-index: 0
机构: FREE UNIV BRUSSELS,DEPT BIOL MOL,PHYSIOL ANIM LAB,B-1640 RHODE ST GENESE,BELGIUM

Moser, M
论文数: 0 引用数: 0
h-index: 0
机构: FREE UNIV BRUSSELS,DEPT BIOL MOL,PHYSIOL ANIM LAB,B-1640 RHODE ST GENESE,BELGIUM
[9]
Toll-like receptor expression in murine DC subsets:: lack of TLR7 expression by CD8α+ DC correlates with unresponsiveness to imidazoquinolines
[J].
Edwards, AD
;
Diebold, SS
;
Slack, EMC
;
Tomizawa, H
;
Hemmi, H
;
Kaisho, T
;
Akira, S
;
Sousa, CR
.
EUROPEAN JOURNAL OF IMMUNOLOGY,
2003, 33 (04)
:827-833

Edwards, AD
论文数: 0 引用数: 0
h-index: 0
机构: Canc Res UK, Immunobiol Lab, London Res Inst, Lincolns Inn Fields Labs, London WC2A 3PX, England

Diebold, SS
论文数: 0 引用数: 0
h-index: 0
机构: Canc Res UK, Immunobiol Lab, London Res Inst, Lincolns Inn Fields Labs, London WC2A 3PX, England

Slack, EMC
论文数: 0 引用数: 0
h-index: 0
机构: Canc Res UK, Immunobiol Lab, London Res Inst, Lincolns Inn Fields Labs, London WC2A 3PX, England

Tomizawa, H
论文数: 0 引用数: 0
h-index: 0
机构: Canc Res UK, Immunobiol Lab, London Res Inst, Lincolns Inn Fields Labs, London WC2A 3PX, England

Hemmi, H
论文数: 0 引用数: 0
h-index: 0
机构: Canc Res UK, Immunobiol Lab, London Res Inst, Lincolns Inn Fields Labs, London WC2A 3PX, England

Kaisho, T
论文数: 0 引用数: 0
h-index: 0
机构: Canc Res UK, Immunobiol Lab, London Res Inst, Lincolns Inn Fields Labs, London WC2A 3PX, England

Akira, S
论文数: 0 引用数: 0
h-index: 0
机构: Canc Res UK, Immunobiol Lab, London Res Inst, Lincolns Inn Fields Labs, London WC2A 3PX, England

Sousa, CR
论文数: 0 引用数: 0
h-index: 0
机构: Canc Res UK, Immunobiol Lab, London Res Inst, Lincolns Inn Fields Labs, London WC2A 3PX, England
[10]
Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection
[J].
Ehst, BD
;
Ingulli, E
;
Jenkins, MK
.
AMERICAN JOURNAL OF TRANSPLANTATION,
2003, 3 (11)
:1355-1362

Ehst, BD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Minnesota, Sch Med, Dept Microbiol, Minneapolis, MN 55455 USA

Ingulli, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Minnesota, Sch Med, Dept Microbiol, Minneapolis, MN 55455 USA

Jenkins, MK
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Sch Med, Dept Microbiol, Minneapolis, MN 55455 USA Univ Minnesota, Sch Med, Dept Microbiol, Minneapolis, MN 55455 USA