BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia

被引：87

作者：

Rybakowski, Janusz K. ^{[1
]}

机构：

[1] Poznan Univ Med Sci, Dept Adult Psychiat, PL-60572 Poznan, Poland

来源：

PHARMACOGENOMICS | 2008年 / 9卷 / 11期

关键词：

brain-derived neurotrophic factor; mood disorders; schizophrenia; Val66Met polymorphism;

D O I：

10.2217/14622416.9.11.1589

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The brain-derived neurotrophic factor (BDNF) gene has become a candidate gene for molecular-genetic studies of mood disorders and schizophrenia, and also for pharmacogenomics of drugs used in the treatment of these conditions, such as mood-stabilizers in bipolar mood disorder, antidepressants in depression, and antipsychotics in schizophrenia. it has been demonstrated that the functional Val66Met polymorphism of the gene can be associated with a number of clinical and pharmacological phenomena in these illnesses.

引用

页码：1589 / 1593

页数：5

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